The effect of vitamin C-loaded electrospun polycaprolactone/poly (Glycerol Sebacate)fibers for peripheral nerve tissue engineering (Record no. 54719)

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control field MX-MdCICY
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control field 20250625162452.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-20633
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245 10 - TITLE STATEMENT
Title The effect of vitamin C-loaded electrospun polycaprolactone/poly (Glycerol Sebacate)fibers for peripheral nerve tissue engineering
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Volume/sequential designation Journal of Polymers and the Environment, 30(11), p.4763-4773, 2022
520 3# - SUMMARY, ETC.
Summary, etc. Vitamin C (VC)is an essential supplement that plays an important role in cellular processes and functions and has been applied for therapeutic purposes for many years. Recently, the beneficial effects of VC on peripheral nerve regeneration have been gained lots of attention. In this study, electrospun polycaprolactone (PCL)/polyglycerol sebacate (PGS)fibers incorporated with different concentrations of VC (5, 10, and 15 wt. percent)were developed for peripheral nerve tissue engineering. The morphology of the fibers was investigated using scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FTIR), tensile analysis (Young's modulus, ultimate tensile strength (UTS), and elongation at break), release profile of VC from the PCL/PGS fibers, in vitro degradation, water uptake behavior, and contact angle measurements were also studied. 3-(4,5?dimethylthiazol?2?yl)?2,5?diphenyltetrazolium bromide (MTT)assay and SEM were utilized to evaluate the attachment and viability of pheochromocytoma cells (PC12)on the scaffolds. The results showed that all scaffolds had a uniform diameter and mean diameter deceased from 1.24 to 0.88 µm followed by increasing VC. Young's modulus and UTS enhanced with increasing in VC percentage. Contact angle analysis showed that VC increased the surface hydrophilicity of PCL/PGS fibers from 31.4º to 13.6º. MTT assays demonstrated that PCL/PGS containing 5 wt. percent VC have a greater viability rate among other scaffolds. Our outcome indicated possible applicability of VC containing scaffolds for nerve tissue engineering.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Alipour, H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Saudi, A.
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Personal name Mirazi, H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kazemi, M. H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Alavi, O.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Zeraatpisheh, Z.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Rafienia, M.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1WE_u9f771hzPbyjRK-FZfLXRwXET1Cfr/view?usp=drivesdk">https://drive.google.com/file/d/1WE_u9f771hzPbyjRK-FZfLXRwXET1Cfr/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-20633 25.06.2025 25.06.2025 Documentos solicitados