The protective effect of C-phycocyanin in male mouse reproductive system (Record no. 54802)
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| 000 -LEADER | |
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| fixed length control field | 02254nam a2200241Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162454.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-20720 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | The protective effect of C-phycocyanin in male mouse reproductive system |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Food & Function, 13(5), p.2631-2646, 2022 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | C-phycocyanin from Spirulina platensis has pharmacological effects such as anti-oxidation, anti-cancer, anti-inflammatory and anti-atherosclerosis activities as well as liver and kidney protection. However, there is little research on C-phycocyanin applied in the field of reproductive medicine, and it is therefore the focus of the current study. In this study, a GC-1 spg cell model and male mouse reproductive injury model were constructed by TNF ? + Smac mimetic + zVAD-fmk (TSZ)and cyclophosphamide (Cy), respectively. It has been proved that C-phycocyanin can increase cell viability and reduce cell death in GC-1 spg cells induced by TSZ. C-phycocyanin could protect the reproductive system of male mice from cyclophosphamide, improve spermatogenesis, sperm quality and fertility, increase the release of testosterone, stabilize the feedback regulation mechanism, and ensure the spermatogenic ability of mice. It could also improve the ability of anti-oxidation. In addition, C-phycocyanin could play a protective role by down-regulating RIPK1, RIPK3, and p-MLKL to inhibit the necroptotic signaling pathway. These results suggest that C-phycocyanin could protect GC-1 spg cells and the reproductive system of male mice from TSZ and cyclophosphamide, and the protective mechanism may be achieved by inhibiting the signal pathway of necroptosis. Therefore, C-phycocyanin could serve as a promising reproductive system protective agent. C-phycocyanin may enter public life as a health product in the future. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yang, F. H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dong, X. L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu, G. X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Teng, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhu, F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, B. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1-vT9y3xgT2QMPQhq29Gqe8i7yoG_1sms/view?usp=drivesdk">https://drive.google.com/file/d/1-vT9y3xgT2QMPQhq29Gqe8i7yoG_1sms/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-20720 | 25.06.2025 | 25.06.2025 | Documentos solicitados |