MARC details
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02283nam a2200265Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625162455.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-20811 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Photophysical, Theoretical, Pharmacogenomics And Biological Studies Of Synthesized New Symmetrical Diol Schiff Base And 4-Arylidene Curcumin Monomers |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Journal of Molecular Structure, 1218, p.128491, 2020 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
This research work was emphasized about two different new symmetrical diol monomers: (i)Schiff base monomers (1a-1d)and (ii)4-Arylidine curcumin monomers (2a, 2b). Formulations of all monomers have been deduced by elemental analysis and spectral data (FT IR, 1H NMR, 13C NMR, and GC/MS spectroscopy). Investigations on photophysical properties of monomers have been studied in THF using steady state absorption, fluorescence, and excited-state time-resolved fluorescence techniques. The chemical stability of title compounds was accomplished by DFT theory using B3LYP/3-21G?++ basis sets. All the monomers were strongly interacted with HSA a compound 2a higher negative docking score is considered as more potent. The monomers (1a-1d 2a, 2b)which that approved through docking profiles have examined their potency against A549 and cervical HeLa cancer and normal monkey kidney cells by in vitro. The compound 2a showed a highest potency against the A549 cell line with the IC50 value 18.81 percent. These results matched well with the results observed from molecular docking studies. Additionally, the proposed set of monomers optimized by virtual ADMET screening and molecular simulation methods. Hence, the overall present study paves the way for designing new drugs for anticancer and antimycobacterial activities with elevated inhibitory potency. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PHOTOPHYSICAL PROPERTIES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ANTICANCER ACTIVITY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ADMET |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
AUTO DOCKING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DENSITY FUNCTIONAL THEORY |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Subramani, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Ali, L. B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Rosi, V. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Shabeer, T. K. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1hqRE0sP6gdq67y-GUS8ja-_IN9rD6FHN/view?usp=drivesdk">https://drive.google.com/file/d/1hqRE0sP6gdq67y-GUS8ja-_IN9rD6FHN/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
