Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells (Record no. 54902)

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control field MX-MdCICY
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control field 20250625162456.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-20822
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Title Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells
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Volume/sequential designation BioChemical and biophysical Research Communications, 234(3), p.641-645, 1997
520 3# - SUMMARY, ETC.
Summary, etc. In a previous study, we showed that geranylgeraniol (GGO)is a potent inducer of apoptosis in human leukemia cells. The present study describes the effects of GGO on the activity of cysteine-dependent aspartate-directed proteases (caspases)in human leukemia U937 cells. The caspase-3 (CPP32)activity was increased in a time-dependent manner by treatment with 50 microM GGO, whereas no activation of caspase-1 (interleukin-1beta converting enzyme (ICE)) was observed in any time period under the same experimental conditions. Other isoprenyl compounds such as geraniol, geranylgerany-lacetone, and vitamin K2 had no measurable effects on the activities of either caspase-3 or caspase-1. A inhibitor that preferentially inhibits the caspase-3 related caspases, Z-DEVD-FMK, strongly blocked the GGO-induced DNA fragmentation. These results suggest the involvement of caspase-3 in GGO-induced apoptosis in U937 human leukemia cells.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Masuda, Y.
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Personal name Nakaya, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Nakajo, S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Nakaya, K.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1NSpOtpMT9qe_mtz-4Dd7frPDzz0n5Dx_/view?usp=drivesdk">https://drive.google.com/file/d/1NSpOtpMT9qe_mtz-4Dd7frPDzz0n5Dx_/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-20822 25.06.2025 25.06.2025 Documentos solicitados