Geranylgeraniol is a potent inducer of apoptosis in tumor cells (Record no. 54904)

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fixed length control field 01418nam a2200277Ia 4500
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control field MX-MdCICY
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control field 20250625162456.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-20824
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245 10 - TITLE STATEMENT
Title Geranylgeraniol is a potent inducer of apoptosis in tumor cells
490 0# - SERIES STATEMENT
Volume/sequential designation The Journal of BioChemistry, 117(1), p.11-13, 1995
520 3# - SUMMARY, ETC.
Summary, etc. We screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol)had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent. DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element APOPTOSIS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GERANYLGERANIOL
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Topical term or geographic name entry element ISOPRENOID
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TUMOR CELL
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ohizumi, H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Masuda, Y.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Nakajo, S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sakai, I.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ohsawa, S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Nakaya, K.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1rU3s55qtDLZw_f82xYrSIGH2pxFOOLAW/view?usp=drivesdk">https://drive.google.com/file/d/1rU3s55qtDLZw_f82xYrSIGH2pxFOOLAW/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-20824 25.06.2025 25.06.2025 Documentos solicitados