Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment (Record no. 54944)
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| fixed length control field | 01975nam a2200241Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162456.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-20864 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Cell Metabolism, https://doi.org/10.1016/j.cmet.2023.12.026, 2023 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The brain and gut are intricately connected and respond to various stimuli. Stress-induced brain-gut communication is implicated in the pathogenesis and relapse of gut disorders. The mechanism that relays psychological stress to the intestinal epithelium, resulting in maladaptation, remains poorly understood. Here, we describe a stress-responsive brain-to-gut metabolic axis that impairs intestinal stem cell (ISC)lineage commitment. Psychological stress-triggered sympathetic output enriches gut commensal Lactobacillus murinus, increasing the production of indole-3-acetate (IAA), which contributes to a transferrable loss of intestinal secretory cells. Bacterial IAA disrupts ISC mitochondrial bioenergetics and thereby prevents secretory lineage commitment in a cell-intrinsic manner. Oral ?-ketoglutarate supplementation bolsters ISC differentiation and confers resilience to stress-triggered intestinal epithelial injury. We confirm that fecal IAA is higher in patients with mental distress and is correlated with gut dysfunction. These findings uncover a microbe-mediated brain-gut pathway that could be therapeutically targeted for stress-driven gut-brain comorbidities. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wei, W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hou, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cao, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hao, H. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/17mC52E6zuJXIQGD__UTO6a02LqlU0fBd/view?usp=drivesdk">https://drive.google.com/file/d/17mC52E6zuJXIQGD__UTO6a02LqlU0fBd/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-20864 | 25.06.2025 | 25.06.2025 | Documentos solicitados |