MARC details
| 000 -LEADER |
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| fixed length control field |
02597nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625162458.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-20934 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Chemical Characterization, DNA-Damage Protection, Antiproliferative Activity and in Silico Studies of the Essential Oils from Perralderia coronopifolia Coss |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Chemistry & BioDiversity, 21(2), p.e202301535, 2024 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
In this study, for the first time, we analyzed the chemical composition of essential oils (EOs)steam-distilled from the flowers and leaves of Perralderia coronopifolia by GC-FID/MS. The objective was to explore new anticancer and antioxidant bioactive substances and understand their mechanisms of action through the use of plant-derived natural products. The major chemical components characterizing the EOs were cis-chrysanthenyl acetate 1, 6-oxocyclonerolidol 2, cis-8-acetoxychrysanthenyl acetate 3, and 6?-hydroxycyclonerolidol 4, respectively. Furthermore, the EOs inhibited cell proliferation in HeLa (human cervix carcinoma)and PC3 (human prostate cancer)cells and protected plasmid DNA from oxidative damage caused by UV-photolyzed H2 O2 . Employing a molecular docking study, we elucidated the main compounds' inhibition mechanisms. Consequently, the antitumor activity could be related to the inhibitory property of compound 3 against CDC25B phosphatase. The evaluation of ADMET (absorption, distribution, metabolism, excretion, and toxicity)properties and the density functional theory (DFT)calculations of the major compounds, especially compound 3, offer potential insights for designing and developing new cancer drug candidates. In conclusion, our study provides a framework for future research and development in the field by establishing a scientific foundation for the use of Perralderia coronopifolia essential oils as a prospective source of antioxidant and anticancer agents. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ANTIPROLIFERATIVE ACTIVITY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DFT AND ADMET STUDIES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MOLECULAR DOCKING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PERRALDERIA CORONOPIFOLIA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PERRALDERIA CORONOPIFOLIA OILS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CIS-8-ACETOXYCHRYSANTHENYL ACETATE |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Boussaha, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Lassed, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Abdelwahab, A. B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Krid, A. Altun, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chalard, P. P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Benayache, P. F. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/17P7pvFjS5vSo_8ibE9g1M637YETNuegv/view?usp=drivesdk">https://drive.google.com/file/d/17P7pvFjS5vSo_8ibE9g1M637YETNuegv/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
