k-carrageenan-C-phycocyanin based smart injectable hydrogels for accelerated wound recovery and real-time monitoring (Record no. 55050)
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| 000 -LEADER | |
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| fixed length control field | 03480nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162458.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-20971 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | k-carrageenan-C-phycocyanin based smart injectable hydrogels for accelerated wound recovery and real-time monitoring |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Acta Biomaterialia, 109, p.121-131, 2020 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Wound healing remains a healthcare challenge in patients suffering from grave tissue damage due to burn injuries and severe medical conditions like diabetes and ischemia. A repeated wound dressing in such cases leads to tissue damage, which could further inflate the wound healing. It is also challenging to analyze the depth of wound bed in these conditions, which could affect the recovery period. To address this need, we have developed an injectable hydrogel from natural polysaccharide ?-carrageenan and a pigmented protein C-phycocyanin. C-phycocyanin has wound healing, antimicrobial, antioxidant and anti-inflammatory properties along with the In-vivo fluorescence imaging ability. Gelling property of ?-carrageenan could be utilized along with C-phycocyanin as an injectable and regenerative wound dressings matrix to monitor wound healing in real-time without upsetting the healing process. The hydrogel presented herein was built from ionic crosslinking of ?-carrageenan monomers along with C-phycocyanin, which provides an interconnected network of porous material with hydrophilic surface and mechanical stiffness. This porosity allows nutrients transportation and gaseous exchange across the wound healing site for the proliferation of various cells. Hydrogel material enhances the proliferation of dermal fibroblasts in vitro without inducing inflammation along with reducing the blood clotting time with no haemolysis. We have found that ?-carrageenan-C-phycocyanin (?-CRG-C-Pc)hydrogel not only exhibit superior haemostatic capabilities in traumatic injury condition but also provide support for rapid wound healing. Overall, these findings demonstrate the potential of ?-carrageenan-C-phycocyanin hydrogels as a wound-healing and imaging platform towards accelerating tissue repair and real-time monitoring. STATEMENT OF SIGNIFICANCE: Blood clotting and inflammation are the most crucial stages of wound healing along with appropriate monitoring of the healing process. Thus, there is a need of system that could provide point-to-point care and monitoring in this multistage process. Here, we have introduced a self healing, injectable hydrogel system with in vivo imaging abilities from ?-carragenan and C-phycocyanin. C-phycocyanin improves the stability of ?-carragenan matrix and provide support to cellular adhesion, proliferation, and migration. Its anti-inflammatory response and rapid blood clotting ability further empower its applicability in critical medical conditions and wound recovery. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | C-PHYCOCYANIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | HYDROGEL |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | IN VIVO IMAGING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | WOUND HEALING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | K-CARRAGEENAN |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dev, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohanbhai, S. J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kushwaha, A. C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sood, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sardoiwala, M. N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Choudhury, S. R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Karmakar, S. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/10ZQZIzkKZ-y8tkUs3UVgCouNZd3WhtAH/view?usp=drivesdk">https://drive.google.com/file/d/10ZQZIzkKZ-y8tkUs3UVgCouNZd3WhtAH/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-20971 | 25.06.2025 | 25.06.2025 | Documentos solicitados |