Antiviral profiling of C-18-or C-19-functionalized semisynthetic Abietane diterpenoids (Record no. 55084)
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| 000 -LEADER | |
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| fixed length control field | 02029nam a2200241Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162459.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-21006 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Antiviral profiling of C-18-or C-19-functionalized semisynthetic Abietane diterpenoids |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Journal of Natural Products, 85(8), p.2044-2051, 2022 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Viral infections affect several million patients annually.Although hundreds of viruses are known to be pathogenic, only a few can be treated in the clinic with available antiviral drugs. Naturally based pharmacotherapy may be a proper alternative for treating viral diseases.Several natural and semisynthetic abietane-type diterpenoids have shown important antiviral activities. In this study, a biological evaluation of a number of either C-18- or C-19-functionalized known semisynthetic abietanes against Zika virus, Dengue virus, Herpes virus simplex type 1, and Chikungunya virus are reported. Semisynthetic abietane ferruginol and its analogue 18-(phthalimid-2-yl)ferruginol displayed broad-spectrum antiviral properties. The scale-up synthesis of this analogue has been optimized for further studies and development. This molecule displayed an EC50 between 5.0 and 10.0 ?M against Colombian Zika virus strains and EC50 = 9.8 ?M against Chikungunya virus. Knowing that this ferruginol analogue is also active against Dengue virus type 2 (EC50 = 1.4 ?M, DENV-2), we can conclude that this compound is a promising broad-spectrum antiviral agent paving the way for the development of novel antivirals. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | González-Cardenete, M. A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hamulic, D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Miquel-Leal, F. J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | González-Zapata, N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jimenez-Jarava, O. J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Brand, Y. M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marín, M. L. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/open?id=1VW4MY8sWRhORrlyjOGdmzaA_N9M8ooO_&usp=drive_copy">https://drive.google.com/open?id=1VW4MY8sWRhORrlyjOGdmzaA_N9M8ooO_&usp=drive_copy</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-21006 | 25.06.2025 | 25.06.2025 | Documentos solicitados |