Targeted delivery of phycocyanin for the prevention of colon cancer using electrospun fibers (Record no. 55232)

MARC details
000 -LEADER
fixed length control field 01733nam a2200241Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162502.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-21155
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250602s9999 xx |||||s2 |||| ||und|d
245 10 - TITLE STATEMENT
Title Targeted delivery of phycocyanin for the prevention of colon cancer using electrospun fibers
490 0# - SERIES STATEMENT
Volume/sequential designation Food & function, 10(4), p.1816-1825, 2019
520 3# - SUMMARY, ETC.
Summary, etc. Phycocyanin (PC), a water-soluble biliprotein, exhibits potent anti-colon cancer properties. However, its application in functional foods is limited by the poor stability and low bioavailability of PC. In this study, we successfully encapsulated PC by coaxial electrospinning. The colon targeted release of PC was achieved with retention of the antioxidant activity of PC. The PC-loaded electrospun fiber mat (EFM)obtained inhibited HCT116 cell growth in a dose-dependent and time-dependent manner. In particular, the PC-loaded EFM exerted its anti-cancer activity by blocking the cell cycle at the G0/G1 phase and inducing cell apoptosis involving the decrease of Bcl-2/Bax, activation of caspase 3 and release of cytochrome c. This study suggests that co-axial electrospinning is an efficient and effective way to deliver PC and improve its bioavailability; thus, it represents a promising approach for encapsulating functional ingredients for colon cancer prevention
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wen, P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Hu, T. G.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wen, Y.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Linhardt, R. J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Zong, M. H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Zou, Y. X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wu, H.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/open?id=1WHs64WU78fvctyU2F1RFWP2PBhIBn582&usp=drive_copy">https://drive.google.com/open?id=1WHs64WU78fvctyU2F1RFWP2PBhIBn582&usp=drive_copy</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-21155 25.06.2025 25.06.2025 Documentos solicitados