MARC details
| 000 -LEADER |
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| fixed length control field |
02290nam a2200313Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625162502.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-21156 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Encapsulation of phycocyanin by prebiotics and polysaccharides-based electrospun fibers and improved colon cancer prevention effects |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
International Journal of Biological Macromolecules, 149, p.672-681, 2020 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
To preserve bioactivity and achieve colon targeted release of phycocyanin (PC), the polysaccharides-based electrospun fiber mat (EFM)containing PC and prebiotics was prepared and characterized. In vitro release tests confirmed the colon targeting behavior of PC, in particular, faster release of PC was achieved due to the addition of prebiotics. Ritger-Peppas model confirmed that the release of PC in simulated colon fluids follows a mechanism of anomalous transport (non-Fickian). CCK-8 results showed that the combination of PC and prebiotics exerted a significant anti-proliferative effect on HCT116 cells with an IC50 values of 22.31, 17.12 and 11.63 mg/mL after 24, 48, and 72 h, respectively. Furthermore, the cell cycle and apoptosis analysis revealed that the inhibition activity on HCT116 cells was caused by arresting cell cycle at G0/G1 phase that is relevant to the inhibition of cyclin D1 and CDK4 and the up-regulation of p21 expression, and inducing cell apoptosis by mediating the mitochondrial pathway as well, in which the decrease of Bcl-2/Bax, activation of caspase 3 and release of cytochrome c were included. This study suggests that the PC-loaded EFM with GOS holds a great potential as an effective formulation for colon cancer prevention. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
APOPTOSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CANCER PREVENTION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CELL CYCLE ARREST |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
COAXIAL ELECTROSPINNING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PHYCOCYANIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PREBIOTICS |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wen, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wen, P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hu, T. G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Linhardt, R. J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zong, M. H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wu, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chen, Z. Y. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/open?id=1gVLiw82pqXnBKVEAjy_6-3o_-F5Bnjxe&usp=drive_copy">https://drive.google.com/open?id=1gVLiw82pqXnBKVEAjy_6-3o_-F5Bnjxe&usp=drive_copy</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
