MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02832nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20250625164351.0 |
| 040 ## - CATALOGING SOURCE |
|---|
| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-21232 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Natural deep eutectic solvents-based selective extraction of saponins from Panax notoginseng: Process optimization, chemical profiling, and bioactivities evaluation |
| 490 0# - SERIES STATEMENT |
|---|
| Series statement |
Separation and Purification Technology. 341, 126882, 2024, DOI: 10.1016/j.seppur.2024.126882 |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
In this study, we employed ultrasound-assisted extraction in conjunction with natural deep eutectic solvents (NADES) to investigate an innovative and sustainable approach for the selective extraction of Panax notoginseng (PN) saponins. Fifteen NADES were prepared, of which choline chloride-urea (ChCl-Ur) was selected as the optimal solvent because of the higher solubility of PN saponins. Response surface methodology using Box-Behnken design was adopted to optimize the extraction process. According to the results, NADES with a water content of 45 % (v/v) and a ChCl/Ur ratio of 1:2 (mol/mol) exhibited superior efficacy as a solvent for extracting saponins from PN. The optimal extraction conditions include a liquid-solid ratio of 40 mL/g, an extraction temperature of 47 °C, and an extraction duration of 36 min. The extraction efficiency of NADES for saponins was superior to that of water and comparable to that of 70 % (v/v) methanol. Additionally, we assessed the anti-inflammatory and anticoagulant properties of the resulting extraction solution. The TNF-? and IL-1? inhibiting test showed that the NADES extract of saponins exhibited a stronger inhibitory effect on the mRNA expression of inflammatory cytokines TNF-? and IL-1? when compared to an aqueous extract. And a dose-dependent relationship was observed. In the anticoagulation activity assay, the NADES extract of saponins at a concentration of 25 mg/mL significantly prolonged the activated partial thromboplastin time (p < 0.05). Additionally, concentrations of 12.5 and 25 mg/mL exhibited significant prolongation of the prothrombin time (p < 0.01). These findings suggest that NADES can be used as a solvent to extract PN saponins in an efficient way, and the specific concentrations of the extract possess potent bioactivities. © 2024 Elsevier B.V. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
BIOACTIVITIES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
NATURAL DEEP EUTECTIC SOLVENTS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
PANAX NOTOGINSENG |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
SAPONINS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
ULTRASOUND-ASSISTED EXTRACTION |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Li M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Rao C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Wang C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Cui X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Xiong Y. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1fM8MQxGDtdquk5hK09YkksdDM9t02B7l/view?usp=drivesdk">https://drive.google.com/file/d/1fM8MQxGDtdquk5hK09YkksdDM9t02B7l/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
