Gelatin microsphere-alginate hydrogel combined system for sustained and gastric targeted delivery of 5-fluorouracil (Record no. 55349)

MARC details
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control field MX-MdCICY
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control field 20250625164352.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-21281
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Title Gelatin microsphere-alginate hydrogel combined system for sustained and gastric targeted delivery of 5-fluorouracil
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Series statement International Journal of Biological Macromolecules. 255, 128022, 2024, DOI: 10.1016/j.ijbiomac.2023.128022
520 3# - SUMMARY, ETC.
Summary, etc. In the current study, novel gelatin microspheres/methacrylated alginate hydrogel combined system (5-FU-GELms/Alg-MA) was developed for gastric targeted delivery of 5-fluorouracil as an anticancer agent. While water-in-oil emulsification method was used for the production of 5-FU-GELms, Alg-MA was synthesized through methacrylation reaction occurred by epoxide ring-opening mechanism. Then, 5-FU-GELms/Alg-MA hydrogel system was fabricated by the encapsulation of 5-FU-GELms into Alg-MA hydrogel network via UV-crosslinking. To evaluate applicability of fabricated 5-FU-GELms/Alg-MA as gastric targeted drug delivery vehicle, both swelling and in vitro drug release experiments were carried out at pH 1.2 medium resembling gastric fluid. Compared to drug release directly from 5-FU-GELms, 5-FU-GELms/Alg-MA hydrogel system showed more controlled and sustained drug release profile with lower amount of cumulative release starting from early stages, since hydrogel matrix created a barrier to the diffusion of 5-FU included in microspheres. Drug release kinetic results obtained by applying various kinetic models to release data showed that the mechanism of 5-FU release from 5-FU-GELms/Alg-MA hydrogel system is controlled by Fickian diffusion. All results revealed that 5-FU-GELms/Alg-MA hydrogel integrated system could be potentially utilized as gastric targeted drug carrier to enhance therapeutic efficacy and reduce systemic side effects in gastric cancer treatments for future studies. © 2023 Elsevier B.V.
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Topical term or geographic name entry element ALGINATE
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Topical term or geographic name entry element GELATIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MICROSPHERE-HYDROGEL SYSTEM
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Aycan D.
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Personal name Gül ?.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Yorulmaz V.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Alemdar N.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1i9ZaGqZypuvA6Uqf6SQWvTRQ2qU-cvA4/view?usp=drivesdk">https://drive.google.com/file/d/1i9ZaGqZypuvA6Uqf6SQWvTRQ2qU-cvA4/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-21281 25.06.2025 25.06.2025 Documentos solicitados