Evaluation of gelatin microspheres for nasal and intramuscular administrations of salmon calcitonin (Record no. 55352)
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| 000 -LEADER | |
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| fixed length control field | 03209nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625164352.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-21284 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of gelatin microspheres for nasal and intramuscular administrations of salmon calcitonin |
| 490 0# - SERIES STATEMENT | |
| Series statement | European Journal of Pharmaceutical Sciences. 13(2), 179-185, 2001, DOI: 10.1016/S0928-0987(01)00094-X |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The suitability of gelatin microspheres for nasal and intramuscular delivery of salmon calcitonin (sCT) was examined. Negatively and positively charged gelatin microspheres were prepared using acidic gelatin [isoelectric point (IEP) value of 5.0] and basic gelatin (IEP=9.0), respectively. The average diameters of positively charged gelatin microspheres in their dried state were 3.4, 11.2, 22.5 and 71.5 ?m, while that of negatively charged gelatin microspheres was 10.9 ?m. Both types of gelatin microspheres were capable of adhering to the nasal mucosa. The mucoadhesion of positively charged gelatin microspheres was significantly higher than that of their negatively charged counterparts. The absorption of sCT after intranasal and intramuscular administration was evaluated by calculating the area above the hypocalcemic-time curve (AAC) in rats. The AAC values after nasal administration of sCT in positively and negatively charged gelatin microspheres were significantly greater than that in pH 7.0 PBS. Therefore, the nasal absorption of sCT was enhanced by both types of gelatin microspheres. The hypocalcemic effect after administration of sCT in positively charged gelatin microspheres of 11.2 ?m was significantly greater than that of negatively charged gelatin microspheres of the same size. On the other hand, AAC values were not affected by their particle sizes. The AAC values after the intramuscular administration of sCT in positively and negatively charged gelatin microspheres were significantly increased compared to that in PBS. Furthermore, the time-courses of the plasma calcium levels differed between positively and negatively charged gelatin microspheres. The hypocalcemic effect of the negatively charged gelatin microspheres tended to appear more slowly and last longer compared to that of positively charged gelatin microspheres. The hypocalcemic effects after intramuscular administration of sCT in gelatin microspheres were not affected by their particle sizes as well as those after intranasal administration. In conclusion, the gelatin microspheres have been shown to be a useful vehicle for nasal or intramuscular delivery of sCT. © 2001 Elsevier Science B.V. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | GELATIN, MICROSPHERES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | INTRAMUSCULAR ADMINISTRATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | NASAL DELIVERY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PEPTIDE DRUG |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | SALMON CALCITONIN |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Morimoto K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Katsumata H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yabuta T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iwanaga K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kakemi M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tabata Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ikada Y. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1KPzGlshQs1h769qYcV5VKywas-N16Yg-/view?usp=drivesdk">https://drive.google.com/file/d/1KPzGlshQs1h769qYcV5VKywas-N16Yg-/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-21284 | 25.06.2025 | 25.06.2025 | Documentos solicitados |