Therapeutic potential of antifungal plant and insect defensins (Record no. 55386)

MARC details
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fixed length control field 01605nam a2200217Ia 4500
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control field MX-MdCICY
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control field 20250625164353.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-21321
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Title Therapeutic potential of antifungal plant and insect defensins
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Series statement Drug Discovery Today. 12(21-22), 966-971, 2007, DOI: 10.1016/j.drudis.2007.07.016
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Summary, etc. To defend themselves against invading fungal pathogens, plants and insects largely depend on the production of a wide array of antifungal molecules, including antimicrobial peptides such as defensins. Interestingly, plant and insect defensins display antimicrobial activity not only against plant and insect pathogens but also against human fungal pathogens, including Candida spp. and Aspergillus spp. This review focuses on these defensins as novel leads for antifungal therapeutics. Their mode of action, involving interaction with fungus-specific sphingolipids, and heterologous expression, required for cost-effective production, are major assets for development of plant and insect defensins as antifungal leads. Studies evaluating their in vivo antifungal efficacy demonstrate their therapeutic potential. © 2007 Elsevier Ltd. All rights reserved.
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Personal name Thevissen K.
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Personal name Kristensen H.-H.
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Personal name Thomma B.P.H.J.
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Personal name Cammue B.P.A.
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Personal name François I.E.J.A.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/152N1YZPKhQrpCraHG_pKXlDjLn90vEzD/view?usp=drivesdk">https://drive.google.com/file/d/152N1YZPKhQrpCraHG_pKXlDjLn90vEzD/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-21321 25.06.2025 25.06.2025 Documentos solicitados