MARC details
| 000 -LEADER |
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| fixed length control field |
02832nam a2200469Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625164353.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-21323 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Cytokinin oxidase/dehydrogenase inhibitors: progress towards agricultural practice |
| 490 0# - SERIES STATEMENT |
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| Series statement |
Journal of Experimental Botany. 75(16), 4873-4890, 2024, DOI: 10.1093/jxb/erae239 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Cytokinin oxidase/dehydrogenase (CKX) inhibitors reduce the degradation of cytokinins in plants and thereby may improve the efficiency of agriculture and plant tissue culture-based practices. Here, we report a synthesis and structure-activity relationship study of novel urea derivatives concerning their CKX inhibitory activity. The most active compounds showed sub-nanomolar IC50 values with maize ZmCKX1, the lowest value yet documented. Other CKX isoforms of maize and Arabidopsis were also inhibited very effectively. The binding mode of four compounds was characterized based on high-resolution crystal complex structures. Using the soil nematode Caenorhabditis elegans, and human skin fibroblasts, key CKX inhibitors with low toxicity were identified. These compounds enhanced the shoot regeneration of Lobelia, Drosera, and Plectranthus, as well as the growth of Arabidopsis and Brassica napus. At the same time, a key compound (identified as 82) activated a cytokinin primary response gene, ARR5:GUS, and a cytokinin sensor, TCSv2:GUS, without activating the Arabidopsis cytokinin receptors AHK3 and AHK4. This strongly implies that the effect of compound 82 is due to the up-regulation of cytokinin signalling. Overall, this study identifies highly effective and easily prepared CKX inhibitors with a low risk of environmental toxicity for further investigation of their potential in agriculture and biotechnology. © The Author(s) 2024 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
AGRICULTURE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ARABIDOPSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
BIOSTIMULANT |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
BIOTECHNOLOGY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CKX INHIBITOR |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CYTOKININ |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CYTOKININ OXIDASE/DEHYDROGENASE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DIPHENYLUREA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
NUTRIENT USE EFFICIENCY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
OILSEED RAPE |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Nisler J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Klimeš P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kon?itíková R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kadlecová A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Voller J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chalaki M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Karampelias M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Murvanidze N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Werbrouck S.P.O. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kope?ný D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Havlí?ek L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
De Diego N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Briozzo P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Moréra S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zalabák D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Spíchal L. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1Swf68ZqiP0Xtrhg9UvWv6DS-h2zefvwy/view?usp=drivesdk">https://drive.google.com/file/d/1Swf68ZqiP0Xtrhg9UvWv6DS-h2zefvwy/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
