MARC details
| 000 -LEADER |
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| fixed length control field |
02549nam a2200325Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625164353.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-21339 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Cytotoxic and anti-inflammatory polyacetylenes from Tridax procumbens L |
| 490 0# - SERIES STATEMENT |
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| Series statement |
Phytochemistry. 225, 114191, 2024, DOI: 10.1016/j.phytochem.2024.114191 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Herein, 17 previously undescribed polyacetylenes and 9 known ones were isolated from Tridax procumbens L. Their structures were identified using spectroscopic techniques (NMR, UV, IR, MS and optical rotation), the modified Mosher method, electronic circular dichroism (ECD) data and ECD calculation. The cytotoxicity of polyacetylenes on six human tumour cell lines (K562, K562/ADR, AGS, MGC-803, SPC-A-1 and MDA-MB-231) was evaluated. (3S,10R)-tridaxin B (2a), (3S,10S)-tridaxin B (2b) and tridaxin F (8) demonstrated substantial cytotoxic effects against the K562 cell line, with half-maximal inhibitory concentration (IC50) values of 2.62, 14.43 and 17.91 ?M, respectively. Cell and nucleus morphology assessments and Western blot analysis confirmed that the cytotoxicity of the three polyacetylenes on K562 cells was mediated through a dose-dependent apoptosis pathway. Furthermore, (3S,10R)-tridaxin A (1a) and tridaxin G (9) exhibited considerable inhibitory effects on lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages, with IC50 values of 15.92 and 20.35 ?M, respectively. Further investigations revealed that 9 exerted anti-inflammatory activities by impeding the nuclear translocation of NF-?B and down-regulating the expression of pro-inflammatory factors, including those of iNOS, COX-2, IL-1? and IL-6, in a concentration-dependent manner. The study provides evidence that polyacetylenes from T. procumbens may serve as a potential source of anti-tumour or anti-inflammatory agents for treating related diseases. © 2024 Elsevier Ltd |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ANTI-INFLAMMATORY ACTIVITY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ASTERACEAE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
COAT BUTTONS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CYTOTOXICITY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
POLYACETYLENES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TRIDAX PROCUMBENS L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Tan Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chen C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chen L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zeng J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zhang W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Xu J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
He X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wang Y. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1sdgX1D5bKzJd_9LQKNo6peaq-pJwKyjx/view?usp=drivesdk">https://drive.google.com/file/d/1sdgX1D5bKzJd_9LQKNo6peaq-pJwKyjx/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
