Revisiting the shikimate pathway and highlighting their enzyme inhibitors (Record no. 55404)

MARC details
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fixed length control field 02087nam a2200289Ia 4500
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control field MX-MdCICY
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control field 20250625164353.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-21340
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Title Revisiting the shikimate pathway and highlighting their enzyme inhibitors
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Series statement Phytochemistry Reviews. 23(2), 421-457, 2024, DOI: 10.1007/s11101-023-09889-6
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Summary, etc. Absent in animals and with only seven enzymatic reactions toward the synthesis of chorismate and aromatic amino acids, the shikimate pathway is a crucial target for developing antimicrobial agents and herbicides. Although this pathway has been extensively studied in microorganisms related to human health, it reveals complexities in plants, as it takes part in primary and secondary metabolism. Obtaining enzyme inhibitors is essential to circumvent the occurrence of weeds resistant to commercially available herbicides and to help control human diseases, which has challenged researchers to search for new molecules and investigate their modes of action. By applying bioinformatics tools, thousands of enzyme inhibitors of this metabolic pathway can be prospected at a low cost and in a short time. Here, we revisit how the enzymes of the shikimate pathway have been characterized and update the status of their inhibitors in microorganisms and plants. This overview can be constructive in searching for enzyme inhibitors in the academic, human health, and agro-industrial fields. © The Author(s), under exclusive licence to Springer Nature B.V. 2023.
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Topical term or geographic name entry element ANTIMICROBIALS
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Topical term or geographic name entry element BIOINFORMATICS
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Topical term or geographic name entry element ENZYMATIC INHIBITOR
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Topical term or geographic name entry element ENZYMES
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Topical term or geographic name entry element HERBICIDES
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Personal name Almeida A.M.
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Personal name Marchiosi R.
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Personal name Abrahão J.
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Personal name Constantin R.P.
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Personal name dos Santos W.D.
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Personal name Ferrarese-Filho O.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/14XeFq7jGfsXVYvWHZkP_PHGgyC3TnvAk/view?usp=drivesdk">https://drive.google.com/file/d/14XeFq7jGfsXVYvWHZkP_PHGgyC3TnvAk/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-21340 25.06.2025 25.06.2025 Documentos solicitados