MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03378nam a2200349Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20250625164353.0 |
| 040 ## - CATALOGING SOURCE |
|---|
| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-21369 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Unlocking the functional potential of Nitraria schoberi extracts using chemical fingerprinting, biological efficiencies, in silico and network pharmacological approaches |
| 490 0# - SERIES STATEMENT |
|---|
| Series statement |
Food Bioscience. 60, 104278, 2024, DOI: 10.1016/j.fbio.2024.104278 |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
The objective of this investigation was to assess the cytotoxic, antioxidant, and enzyme inhibitory properties of the aerial portions of Nitraria schoberi (family Nitrariaceae). Extracts were prepared by sequential maceration in hexane, dichloromethane (DCM), ethyl acetate and methanol (MeOH) and water extract was prepared by infusion. DCM and MeOH extracts accumulated the highest amount of metabolites where the former was characterized by the presence of octadecyl ferulate (16.96 mg/100 mg), methoxyluteolin (8.48 mg/100 mg) and isorhamnetin (5.35 mg/100 mg) and the alkaloids perlolyrine (5.03 mg/100 mg), (+)-5a-hydroxylemannine (2.43 mg/100 mg) and matrine (2.40 mg/100 mg). Results of antioxidant activity showed that the MeOH extract exerted the highest anti-2,2-diphenyl-1-picrylhydrazyl (DPPH) (28.13 mg Trolox equivalent (TE)/g) and Fe+++ (54.38 mg TE/g) reducing capacity. All extracts exerted significant acetylcholinesterase (3.71-4.37 mg galantamine equivalent (GALAE)/g) and tyrosinase (86.40-109.63 mg kojic acid equivalent (KAE)/g) inhibition activity. The best ?-amylase and ?-glucosidase inhibition was exhibited by the DCM (0.81 mmol ACAE/g) and MeOH (1.34 mmol ACAE/g) extracts respectively. The highest cytotoxic effect was exerted against the breast adenocarcinoma (MDA-MB-231) (IC50: 26.71 ?g/mL) and cervix adenocarcinoma (HELA) (IC50: 29.10 ?g/mL) cell lines by the MeOH and DCM extracts respectively. In addition, we performed molecular docking analysis to understand the interaction between chemical components and tested enzymes and cellular targets for cancer. Chrysoeriol-3-O-rutinoside bound strongly to AChE. Furthermore, a good interaction between vascular endothelial growth factor receptor 2 (VEGFR2) and isovitexin-2?-O-arabinoside was observed. We employed network pharmacology to understand the role of N. schoberi's compounds in neurological disorder like Alzheimer and multiple sclerosis. Therefore, the results of this study indicate that N. schoberi may serve as a viable starting point for the future creation of phytopharmaceuticals that target particular diseases associated with oxidative stress, such as diabetes and certain neurological disorders. © 2024 Elsevier Ltd |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
ANTIOXIDANT |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
ENZYME INHIBITION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
MOLECULAR DOCKING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
NETWORK PHARMACOLOGY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
NITRARIA SCHOBERI |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
PHYTOCONSTITUENTS |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dall'Acqua S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Yagi S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sut S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Uba A.I. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Yildiztugay E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Koyuncu I. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Yuksekdag O. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ponniya S.K.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Jayavel A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Zengin G. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1JqGIVH07upMg0boYlrHmGzp6KXrM-OY3/view?usp=drivesdk">https://drive.google.com/file/d/1JqGIVH07upMg0boYlrHmGzp6KXrM-OY3/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
