Systematically amino acid analysis: Advancements in extinction coefficient determination for therapeutic proteins (Record no. 55435)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01509nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625164354.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-21374 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Systematically amino acid analysis: Advancements in extinction coefficient determination for therapeutic proteins |
| 490 0# - SERIES STATEMENT | |
| Series statement | Analytical Biochemistry. 690, 115508, 2024, DOI: 10.1016/j.ab.2024.115508 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Biologicals developers often face challenges in accurately determining the extinction coefficient (EC) measurement. We have successfully improved the precision and robustness of the widely recognized amino acid analysis method for EC determination, through a stepwise optimization process. Extensive analyses based on 114 observations, covering eight proteins over three years were performed, with a maximum relative standard deviation of 1.5% among multiple analysts, and a maximum deviation of 2.8% from the theoretical EC across the eight given proteins examined. © 2024 Elsevier Inc. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | AMINO ACID ANALYSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | EXTINCTION COEFFICIENT |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PROTEIN QUANTITY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | THERAPEUTIC PROTEINS |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xu Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shao Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cao Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang Z. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1DN9_ICCoE4uOxK7-0n9duOMAK8CGqMek/view?usp=drivesdk">https://drive.google.com/file/d/1DN9_ICCoE4uOxK7-0n9duOMAK8CGqMek/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-21374 | 25.06.2025 | 25.06.2025 | Documentos solicitados |