MARC details
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03603nam a2200361Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20250625164354.0 |
| 040 ## - CATALOGING SOURCE |
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CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-21383 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Using MetaboAnalyst 4.0 for Comprehensive and Integrative Metabolomics Data Analysis |
| 490 0# - SERIES STATEMENT |
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| Series statement |
Current Protocols in Bioinformatics. 68(1), e86, 2019, DOI: 10.1002/cpbi.86 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
MetaboAnalyst (https://www.metaboanalyst.ca) is an easy-to-use web-based tool suite for comprehensive metabolomic data analysis, interpretation, and integration with other omics data. Since its first release in 2009, MetaboAnalyst has evolved significantly to meet the ever-expanding bioinformatics demands from the rapidly growing metabolomics community. In addition to providing a variety of data processing and normalization procedures, MetaboAnalyst supports a wide array of functions for statistical, functional, as well as data visualization tasks. Some of the most widely used approaches include PCA (principal component analysis), PLS-DA (partial least squares discriminant analysis), clustering analysis and visualization, MSEA (metabolite set enrichment analysis), MetPA (metabolic pathway analysis), biomarker selection via ROC (receiver operating characteristic) curve analysis, as well as time series and power analysis. The current version of MetaboAnalyst (4.0) features a complete overhaul of the user interface and significantly expanded underlying knowledge bases (compound database, pathway libraries, and metabolite sets). Three new modules have been added to support pathway activity prediction directly from mass peaks, biomarker meta-analysis, and network-based multi-omics data integration. To enable more transparent and reproducible analysis of metabolomic data, we have released a companion R package (MetaboAnalystR) to complement the web-based application. This article provides an overview of the main functional modules and the general workflow of MetaboAnalyst 4.0, followed by 12 detailed protocols: © 2019 by John Wiley & Sons, Inc. Basic Protocol 1: Data uploading, processing, and normalization. Basic Protocol 2: Identification of significant variables. Basic Protocol 3: Multivariate exploratory data analysis. Basic Protocol 4: Functional interpretation of metabolomic data. Basic Protocol 5: Biomarker analysis based on receiver operating characteristic (ROC) curves. Basic Protocol 6: Time-series and two-factor data analysis. Basic Protocol 7: Sample size estimation and power analysis. Basic Protocol 8: Joint pathway analysis. Basic Protocol 9: MS peaks to pathway activities. Basic Protocol 10: Biomarker meta-analysis. Basic Protocol 11: Knowledge-based network exploration of multi-omics data. Basic Protocol 12: MetaboAnalystR introduction. © 2019 John Wiley & Sons, Inc. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
BIOMARKER ANALYSIS |
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CHEMOMETRICS |
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JOINT PATHWAY ANALYSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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META-ANALYSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
METABOLIC PATHWAY ANALYSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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METABOLITE SET ENRICHMENT ANALYSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
METABOLOMICS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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MS PEAKS TO PATHWAYS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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MULTI-OMICS INTEGRATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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NETWORK ANALYSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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POWER ANALYSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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REPRODUCIBLE DATA ANALYSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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ROC CURVE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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WEB APPLICATION |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chong J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wishart D.S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Xia J. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1zQy2Etn1xwpZf5pKOhFfqUd-FL4v7C6o/view?usp=drivesdk">https://drive.google.com/file/d/1zQy2Etn1xwpZf5pKOhFfqUd-FL4v7C6o/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta @cicy.edu.mx |
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Clasificación local |
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Documentos solicitados |
