Preparation of chitosan/chondroitin sulfate complex microcapsules and application in controlled release of 5-fluorouracil (Record no. 55462)
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| fixed length control field | 02019nam a2200265Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625164354.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-21402 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Preparation of chitosan/chondroitin sulfate complex microcapsules and application in controlled release of 5-fluorouracil |
| 490 0# - SERIES STATEMENT | |
| Series statement | Carbohydrate Polymers. 80(1), 168-173, 2010, DOI: 10.1016/j.carbpol.2009.11.007 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Chitosan/chondroitin sulfate complex microcapsules were prepared to encapsulate the anti-cancer drug 5-fluorouracil (5-Fu) by emulsion-chemical crosslinking method. The microcapsules were characterized by Fourier transform infrared spectroscopy (IR), scanning electron microscopy (SEM) in conjunction with energy dispersive X-ray spectrometry (EDS), and laser diffraction particle size analysis. The in vitro drug release behavior of 5-Fu from the microcapsules was studied by UV-visible spectrophotometry. Results showed that the microcapsules were in spherical form with diameter mostly in the range of 20-60 ?m. Result of EDS showed that 5-Fu was in the internal core of the microcapsules. The IR spectrum indicated that electrostatic interactions exit between chitosan and chondroitin sulfate, with the sulfate group and free carboxyl group reacted with the amino groups of chitosan. The release kinetic experiments showed that the release performance of the microcapsules was influenced by the amount of crosslinking reagent, drug loading and the pH of the release medium. © 2009 Elsevier Ltd. All rights reserved. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | 5-FLUOROURACIL |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CHITOSAN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CHONDROITIN SULFATE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CONTROLLED RELEASE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MICROCAPSULE |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Huang L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sui W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jiao Q. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1Lz0QP8z0Pdy-A1pc5E8AeWtAaosgL6DY/view?usp=sharing">https://drive.google.com/file/d/1Lz0QP8z0Pdy-A1pc5E8AeWtAaosgL6DY/view?usp=sharing</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-21402 | 25.06.2025 | 25.06.2025 | Documentos solicitados |