MARC details
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02998nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20250626083335.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-21604 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Cuprous oxide nanocomposites with photothermal (PTT) and chemical dynamics (CDT) effects induce cuproptosis in breast cancer using the strategy of increasing inflow and reducing outflow |
| 490 0# - SERIES STATEMENT |
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| Series statement |
Nano Today, 56, p.102223, 2024 |
| 500 ## - GENERAL NOTE |
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| General note |
Artículo |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Chemotherapy is a crucial adjuvant method of treating breast cancer, but it fails to achieve preferable prognosis as the malignant cells eventually develop drug-resistance. Reduced chemotherapeutic sensitivity is primarily caused by endogenous and exogenous resistance during the treatment. Cuproptosis is a newly discovered immunogenic cell death (ICD), characterized by accumulation of copper (Cu) ions inside tumor cells. However, intracellular Cu ion concentrations can hardly reach desired levels to induce cuproptosis due to limited import via existing Cu ionophores and synchronous export via ATP-Cu pump. Herein, our research developed an ele[1]sclomol (ES) loaded cuprous oxide (Cu2O) nanocomposite, called PEG@Cu2O-ES, to solve this dilemma. Our designed PEG@Cu2O-ES could efficiently enter the breast cancer cells, release encapsulated ES and Cu2O, while the photothermal (PTT) effect of Cu2O induced by near-infrared II region (NIR-II) radiation could in turn accelerate the releasing process. Cu2O discharged substantial amounts of Cu in cytoplasm, which directly engaged in the tricarboxylic acid (TCA) cycle in mitochondria, resulting in cuproptosis to some extent. As a result of PTT-enhanced Fenton-like reactions, Cu2O generated a substantial quantity of reactive oxygen species (ROS) that attacked the ATP-Cu pump on cancer cells' membranes, thereby reducing the outflow of Cu ions and aggravating cuproptosis. Additionally, free ES further promoted Cu from the tumor microenvironment (TME) to enter breast cancer cells, and exacerbated cuproptosis with higher efficiency. In vivo, PEG@Cu2O-ES nano[1]composites showed strong anti-tumor effect by inducing cuproptosis, as well as the ability to reprogram the TME and increase the response-sensitivity to programmed cell death protein-1 antibody (αPD-1). In conclusion, this study provides a promising strategy by combining a nano-drug with αPD-1 for sensitizing immunotherapy of chemotherapy-resistant breast cancer. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CUPROPTOSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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REACTIVE OXYGEN SPECIES (ROS) |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TUMOR MICROENVIRONMENT (TME) |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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IMMUNOTHERAPY |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Li, W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Xiao, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Guo, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Peng, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zhu, N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chen, Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Guo, W. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1HMmR-PEqgJuG97BuWmvIJSnpsdZWeq1H/view?usp=drive_link">https://drive.google.com/file/d/1HMmR-PEqgJuG97BuWmvIJSnpsdZWeq1H/view?usp=drive_link</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
