MARC details
| 000 -LEADER |
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| fixed length control field |
02995nam a2200361Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250626090915.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-21680 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Naphthoquinones and derivatives for chemotherapy: perspectives and limitations of their anti-trypanosomatids activities |
| 490 0# - SERIES STATEMENT |
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| Series statement |
Current Pharmaceutical Design, 27(15), p.1807-1824, 2021 |
| 500 ## - GENERAL NOTE |
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| General note |
Artículo |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Chagas disease, Sleeping sickness and Leishmaniasis, caused by trypanosomatids Trypanosoma cruzi, Trypanosoma brucei and leishmania spp., respectively, are considered neglected tropical diseases, and they especially affect impoverished populations in the developing world. The available chemotherapies are very limited, and a search for altematives is still necessary. In folk medicine, natural naphthoquinones have been employed for the treatment of a great variety of illnesses, including parasitic infections. This review is focused on the anti-trypanosomatid activity and mechanistic analysis of naphthoquinones and derivatives. Among ali the series of derivatives tested in vitro, naphthoquinone-derived 1,2,3-triazoles were very active on T. cruzi infective forms in blood bank conditions, as well as in amastigotes of Leishmania spp. naphthoquinones containing a CF, on a phenyl amine ring inhibited T. brucei proliferation in the nano molar range, and naphthopterocarpanquinones stood out for their activity on a range of leishmania species. Sorne of these compounds show.ed a promising selectivity index (SI) (30 to 1900), supporting further analysis in animal models. lndeed, high toxicity to the host and inactivation by blood components are crucial obstacles to be overcome to use naphthoquinones and/or their derivatives for chemotherapy. Multidisciplinary initiatives embracing medicinal chemistry, bioinformatics, biochemistry, and molecular and cellular biology need to be encouraged to allow the optimization of these compounds. Large scale automated tests are pivotal for the efficiency of the screening step, and subsequent evaluation of both the mechanism of action in vitro and pharmacokinetics in vivo is essential for the development of a novel, specific and safe derivative, minimizing adverse effects. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
T. CRUZI |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
LEISHMANIA SPP. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
T. BRUCEI |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CHAGAS DISEASE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
LEISHMANIASIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
SLEEPING SICKNESS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CHEMOTHERAPY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
NAPHTHOQUINONES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
NAPHTHOIMIDAZOLES |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Dantas-Pereira, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Cunha-Junior, E. F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Andrade-Neto, V. V. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Bower, J. F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Jardim, G. A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
da Silva Júnior, E. N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Menna-Barreto, R. F. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1-dVhXwmNViTgnvSY-k_SGPjFpMAIJph8/view?usp=drive_link">https://drive.google.com/file/d/1-dVhXwmNViTgnvSY-k_SGPjFpMAIJph8/view?usp=drive_link</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
