AIDS-related cytomegalovirus encephalitis in the late ART era: A retrospective cohort study at a referral center in Brazil (Record no. 55748)

MARC details
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fixed length control field 02657nam a2200313Ia 4500
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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250626090915.0
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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-21683
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Title AIDS-related cytomegalovirus encephalitis in the late ART era: A retrospective cohort study at a referral center in Brazil
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Series statement International journal of STD & AIDS, 34(4), 229-235, 2023
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General note Artículo
520 3# - SUMMARY, ETC.
Summary, etc. Background: AIDS-related cytomegalovirus (CMV) encephalitis has declined in the combined antiretroviral therapy (ART) era in high-income countries. However, there is scarce information on CMV encephalitis in low- and middle-income countries. The objectives of this study were to identify the prevalence of AIDS-related CMV encephalitis and describe its main features. Methods: This was a retrospective cohort study carried out at a referral center in São Paulo, Brazil. We included adult people living with HIV/AIDS (PLWHA), hospitalized in 2019, with a CD4 cell count ≤100/mm3 and quantitation CMV DNA results in plasma. Cases with compatible neurological manifestations and detection of CMV DNA by polymerase chain reaction (PCR) in cerebrospinal fluid samples were defined as CMV encephalitis. Results: Among 761 PLWHA hospitalized, 248 (32.5 percent) cases were included in this study. Prevalence of CMV encephalitis was 2.4 percent (6/248) among all included cases and 7.7 percent (6/78) among individuals with neurological opportunistic diseases. The six patients with CMV encephalitis were males and had CD4 cell count 50,000 UI/mL plasma. All six cases received anti-CMV therapy (ganciclovir, n = 4; ganciclovir plus foscarnet, n = 2) and five were discharged to home. CMV encephalitis was not uncommon among hospitalized PLWHA with neurological opportunistic diseases. Conclusions: The epidemiological and immunological profile of individuals with CMV encephalitis was similar to that described in the pre-ART era, but in contrast, most cases were treated and discharged from the hospital.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CYTOMEGALOVIRUS
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Topical term or geographic name entry element ENCEPHALITIS
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Topical term or geographic name entry element EPIDEMIOLOGY
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DIAGNOSIS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HIGHLY ACTIVE ANTIRETROVIRAL THERAPY
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BRAZIL
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Personal name Lucas Júnior, R. M.
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Personal name Bogoni, G.
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Personal name Reis Schneider, G. A.
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Personal name Castanheira de Souza, N. F.
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Personal name Carvalho, M. K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Vidal, J. E.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1JMw83Qcg0rdFa_KzhC87JU71XUL0l9Ku/view?usp=drive_link">https://drive.google.com/file/d/1JMw83Qcg0rdFa_KzhC87JU71XUL0l9Ku/view?usp=drive_link</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 26.06.2025   B-21683 26.06.2025 26.06.2025 Documentos solicitados