MARC details
| 000 -LEADER |
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| fixed length control field |
05020nam a22005175i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-0-387-69805-2 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250710084010.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
111207s2012 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780387698052 |
| -- |
99780387698052 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-0-387-69805-2 |
| Source of number or code |
doi |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
614.5999 |
| Edition information |
23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Green, Jeffrey E. |
| Relator term |
editor. |
| 245 10 - TITLE STATEMENT |
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| Title |
Genetically Engineered Mice for Cancer Research |
| Medium |
[recurso electrónico] : |
| Remainder of title |
design, analysis, pathways, validation and pre-clinical testing / |
| Statement of responsibility, etc. |
edited by Jeffrey E. Green, Thomas Ried. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
New York, NY : |
| Name of producer, publisher, distributor, manufacturer |
Springer New York, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2012. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
XX, 632 p. 75 illus., 47 illus. in color. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
recurso en línea |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Foreword -- Preface -- Overview of Designing Genetically-Engineered Mouse Models -- The Use of Cre-loxP Technology and Inducible Systems to Generate Mouse Models of Cancer -- Using Recombineering Technology To Create Genetically Engineered Mouse Models -- Insertional Mutagenesis for Generating Mouse Models of Cancer -- The RCAS/TVA Somatic Gene Transfer Method In Modeling Human Cancer -- Target-selected ENU Mutagenesis to Develop Cancer Models in the Rat -- The Tumor Pathology of Genetically Engineered Mice: Genomic Pathology -- Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping (SKY), FISH, and immunocytochemistry -- Expression Profiling of Mouse Models of Human Cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying Mammary Epithelial Stem and Progenitor Cells -- Differentiation Programs in Development and Cancer -- Roles of p53 and PRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse -- Mouse Models for Colorectal Cancer -- Src family tyrosine kinases: Implications for mammary tumor progression -- Maspin and Suppression of Tumor Metastasis -- Epigenetic Mouse Models -- Modeling Transforming Growth Factor-ß Signaling in Cancer -- Modeling Stromal-Epithelial Interactions.- Utilizing Mouse Models of Human Cancer for Assessing Immune-Modulation of Cancer Development.- Transplanted Tumor Models For Preclinical Drug Testing And The Potential Benefit Of Genetically Engineered Mouse Models -- The Development and Use of Genetically Tractable Pre-Clinical Mouse Models -- Animal Models for Breast Cancer Prevention Resarch -- Oncogene Addiction: Mouse Models and Clinical Relevance for Molecularly Targeted Therapies -- Mouse Models in Preclinical Drug Development- Applications to CNS Models -- Mouse Models of Human Cancer: Role in Pre-clinical Testing and Personalized Medicine -- Mighty, But How Useful? The Emerging Role of Genetically Engineered Mice in Cancer Drug Discovery and Development -- Index. . |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Technological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors. This book provides an overview of the design considerations and technical approaches used to generate these important models of human cancer. These models are designed to recapitulate molecular aberrations in target organs known to drive human cancers. State-of-the-art methods to analyze genome and transcriptome alterations in these models and particular relationships to human cancers are presented. Mouse-human comparisons of tumor pathologies are exemplified. Criteria for selecting relevant models for preclinical studies that might be translatable to the treatment of human cancers are discussed. The topics presented in this book will be invaluable to both newcomers to the field as well as established investigators who use genetically-engineered mouse models to study the development, progression and treatment of cancer. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MEDICINE. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ONCOLOGY. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
HUMAN GENETICS. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MEDICAL LABORATORIES. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MICROBIOLOGY. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MEDICAL PARASITOLOGY. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
BIOCHEMISTRY. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
BIOMEDICINE. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CANCER RESEARCH. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
HUMAN GENETICS. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
LABORATORY MEDICINE. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MEDICAL MICROBIOLOGY. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ANIMAL BIOCHEMISTRY. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
PARASITOLOGY. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ried, Thomas. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9780387698038 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="http://dx.doi.org/10.1007/978-0-387-69805-2">http://dx.doi.org/10.1007/978-0-387-69805-2</a> |
| Public note |
Ver el texto completo en las instalaciones del CICY |
| 912 ## - |
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| -- |
ZDB-2-SBL |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Libros electrónicos |
