Activation of a helper NLR by plant and bacterial TIR immune signaling (Record no. 61910)

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fixed length control field 01579nam a2200181Ia 4500
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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20251009160707.0
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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-21819
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fixed length control field 251009s9999 xx 000 0 und d
245 10 - TITLE STATEMENT
Title Activation of a helper NLR by plant and bacterial TIR immune signaling
490 0# - SERIES STATEMENT
Series statement Science, 386(6728), p.1413-1420, 2024
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General note Artículo
520 3# - SUMMARY, ETC.
Summary, etc. Plant intracellular nucleotide-binding leucine-rich repeat (NLR) receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain sense pathogen effectors to initiate immune signaling. TIR domains across different kingdoms have NADase activities and can produce phosphoribosyl adenosine monophosphate/diphosphate (pRib-AMP/ADP) or cyclic ADPR (cADPR) isomers. The lipase-like proteins EDS1 and PAD4 transduce immune signals from sensor TIR-NLRs to a helper NLR called ADR1, which executes immune function. We report the structure and function of an Arabidopsis EDS1-PAD4-ADR1 (EPA) heterotrimer in complex with pRib-AMP/ADP activated by plant or bacterial TIR signaling. 2′cADPR can be hydrolyzed into pRib-AMP and thus activate EPA signaling. Bacterial TIR domains producing 2′cADPR also activate EPA function. Our findings suggest that 2′cADPR may be the storage form of the unstable signaling molecule pRib-AMP.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Yu, H.;Xu, W.;Chen, S.;Wu, X.;Rao, W.;Liu, X.;Wan, L.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1Gq6M3-McyqcOV8MkXjOq3ioAdLsMyhRH/view?usp=drive_link">https://drive.google.com/file/d/1Gq6M3-McyqcOV8MkXjOq3ioAdLsMyhRH/view?usp=drive_link</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 09.10.2025   B-21819 09.10.2025 09.10.2025 Documentos solicitados