Elevated snoRNA biogenesis is essential in breast cancer (Record no. 61947)

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fixed length control field 02156nam a2200313Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20251009160707.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-21857
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245 10 - TITLE STATEMENT
Title Elevated snoRNA biogenesis is essential in breast cancer
490 0# - SERIES STATEMENT
Series statement Oncogene, 33(1), p.1348-1358, 2014
500 ## - GENERAL NOTE
General note Artículo
520 3# - SUMMARY, ETC.
Summary, etc. Hyperactive ribosomal biogenesis is widely observed in cancer, which has been partly attributed to the increased rDNA transcription by Pol I in cancer. However, whether small nucleolar RNAs (snoRNAs), a class of non-coding RNAs crucial in ribosomal RNA (rRNA) maturation and functionality, are involved in cancer remains elusive. We report that snoRNAs and fibrillarin (FBL, an enzymatic small nucleolar ribonucleoprotein, snoRNP) are frequently overexpressed in both murine and human breast cancer as well as in prostate cancers, and significantly, that this overexpression is essential for tumorigenicity in vitro and in vivo. We demonstrate that when the elevated snoRNA pathway is suppressed, the tumor suppressor p53 can act as a sentinel of snoRNP perturbation, the activation of which mediates the growth inhibitory effect. On the other hand, high level of FBL interferes with the activation of p53 by stress. We further show that p53 activation by FBL knockdown is not only regulated by the ribosomal protein[1]MDM2-mediated protein stabilization pathway, but also by enhanced PTB-dependent, cap-independent translation. Together, our data uncover an essential role of deregulated snoRNA biogenesis in tumors and a new mechanism of nucleolar modulation of p53.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BREAST CÁNCER
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element FIBRILLARIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element NUCLEOLAR STRESS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element P53
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element SNORNA
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Su, H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Xu, T.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ganapathy, S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Shadfan, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Long, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Huang, T. H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Yuan, Z. M.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/13fa2NBfRE9kE1HhmVshhkMbRMznjpyf2/view?usp=drive_link">https://drive.google.com/file/d/13fa2NBfRE9kE1HhmVshhkMbRMznjpyf2/view?usp=drive_link</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 09.10.2025   B-21857 09.10.2025 09.10.2025 Documentos solicitados