MARC details
| 000 -LEADER |
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02776nam a2200313Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251009160707.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-21863 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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251009s9999 xx 000 0 und d |
| 245 10 - TITLE STATEMENT |
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| Title |
SNORD60 promotes the tumorigenesis and progression of endometrial cancer through binding PIK3CA and regulating PI3K/AKT/mTOR signaling pathway. |
| 490 0# - SERIES STATEMENT |
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| Series statement |
Molecular Carcinogenesis 62(4), 413-426, 2023 |
| 500 ## - GENERAL NOTE |
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| General note |
Artículo |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Endometrial carcinoma is a common gynecological malignant tumor, small nucleolar RNAs (snoRNAs) are involved in cancer development. However, researches on the roles of snoRNAs in endometrial carcinoma are limited. The expression levels of snoRNAs in endometrial cancer tissues were analyzed using The Cancer Genome Atlas (TCGA) database. Antisense oligonucleotides (ASOs) and plasmids were used for transfection. Moreover, CCK‐8, EdU, wound‐healing assay, transwell, cell apoptosis, western blotting, and xenograft model were employed to examine the biological functions of related molecules. real‐time reverse transcription polymerase chain reaction and western blotting were performed to detect messenger RNA (mRNA) and protein levels. Including bioinformatics, fluorescence in situ hybridization, RNA pulldown, actinomycin D and RTL‐P assays were also carried out to explore the molecular mechanism. Analysis of data from TCGA showed that the expression level of small nucleolar RNA, C/D box 60 (SNORD60) in endometrial cancer tissues is observably higher than that in normal endometrial tissues. Further research suggested that SNORD60 played a carcinogenic role both in vitro and in vivo, and significantly upregulated the expression of PIK3CA. However, the carcinogenic effects can be reversed by knocking down fibrillarin (FBL) or PIK3CA. SNORD60 forms complexes by binding with 2′‐O‐methyltransferase fibrillarin, thus catalyzes the 2′‐O‐methylation (Nm) modification of PIK3CA mRNA and modulates the PI3K/AKT/mTOR signaling pathway, so as to promote the development of endometrial cancer. In short, SNORD60 might become a new biomarker for the therapy of endometrial cancer in the future and provide new strategies for diagnosis and treatment. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
2′‐O‐METHYLATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ENDOMETRIAL CARCINOMA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
NONCODING RNA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PIK3CA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
SNORNAS |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wu, W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chen, X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Liu, X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Bao, H. J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Li, Q. H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Xian, J. Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chen, S. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1SeLyeCt68HLtUJQKIOC0RWYb_7IAAMbA/view?usp=drive_link">https://drive.google.com/file/d/1SeLyeCt68HLtUJQKIOC0RWYb_7IAAMbA/view?usp=drive_link</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
