MARC details
| 000 -LEADER |
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| fixed length control field |
02170nam a2200313Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251009160708.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-21870 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
251009s9999 xx 000 0 und d |
| 245 10 - TITLE STATEMENT |
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| Title |
Microorganism‐Derived Bisindole Alkaloids With Anticancer Potential and Their Mechanisms: A Comprehensive Review |
| 490 0# - SERIES STATEMENT |
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| Series statement |
Chemistry & Biodiversity, 2025; 0:e202402398 |
| 500 ## - GENERAL NOTE |
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| General note |
Artículo |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Bisindole alkaloids constitute a significant class of natural compounds distinguished by their characteristic bisindole structure and renowned for their anticancer properties. Over the last six decades, researchers have isolated 425 microorganism‐derived bisindole alkaloids (MDBAs). Among them, 187 MDBAs have demonstrated anticancer properties against various in vitro cancer cell lines, primarily by impeding the cell cycle, restraining cell proliferation, and inducing apoptosis and autophagy. These effects are mediated by regulating key targets and signaling pathways such as hypoxia‐inducible factor (HIF)‐1, MAPK, and phosphatidylinositol 3‐kinase (PI3K)/AKT/mTOR. This review provides a comprehensive examination of the sources, chemical diversity, and anticancer properties of these compounds. Furthermore, it summarizes the structure-activity relationship (SAR), druggability, and the mechanisms underlying MDBAs’ anticancer effects. Ultimately, this article aims to furnish a thorough overview of the advancements in the investigation of microorganism‐derived bisindole alkaloids for their continued development and utilization. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ANTICANCER |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CHEMICAL DIVERSITY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MECHANISM |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MICROORGANISM-DERIVED BISINDOLE ALKALOIDS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
STRUCTURE-ACTIVITY RELATIONSHIP |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zhang, Z. L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Xu, H. N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Gong, C. M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Li, Y. Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Song, X. M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Li, Y. M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wang, R. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1fIpLrlVSDLK4jikdKn_liofeuANU_oJT/view?usp=drive_link">https://drive.google.com/file/d/1fIpLrlVSDLK4jikdKn_liofeuANU_oJT/view?usp=drive_link</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
