TIR signaling activates caspase-like immunity in bacteria (Record no. 61971)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01712nam a2200253Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20251009160708.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-21882 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251009s9999 xx 000 0 und d |
| 245 10 - TITLE STATEMENT | |
| Title | TIR signaling activates caspase-like immunity in bacteria |
| 490 0# - SERIES STATEMENT | |
| Series statement | Science, 387(6733), 510-516, 2025 |
| 500 ## - GENERAL NOTE | |
| General note | Artículo |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Caspase family proteases and Toll/interleukin-1 receptor (TIR)-domain proteins have central roles in innate immunity and regulated cell death in humans. We describe a bacterial immune system comprising both a caspase-like protease and a TIR-domain protein. We found that the TIR protein, once it recognizes phage invasion, produces the previously unknown immune signaling molecule adenosine 5′-diphosphate-cyclo[N7:1′′]-ribose (N7-cADPR). This molecule specifically activates the bacterial caspase-like protease, which then indiscriminately degrades cellular proteins to halt phage replication. The TIR-caspase defense system, which we denote as type IV Thoeris, is abundant in bacteria and efficiently protects against phage propagation. Our study highlights the diversity of TIR-produced immune signaling molecules and demonstrates that cell death regulated by proteases of the caspase family is an ancient mechanism of innate immunity. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rousset, F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Osterman, I. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Scherf, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Falkovich, A. H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Leavitt, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amitai, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sorek, R. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/11sxSE5A98uTJoK2brLBXGJMy0IRS1sxU/view?usp=drive_link">https://drive.google.com/file/d/11sxSE5A98uTJoK2brLBXGJMy0IRS1sxU/view?usp=drive_link</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 09.10.2025 | B-21882 | 09.10.2025 | 09.10.2025 | Documentos solicitados |