MARC details
| 000 -LEADER |
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| fixed length control field |
02404nam a2200337Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251009160708.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-21900 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
251009s9999 xx 000 0 und d |
| 245 10 - TITLE STATEMENT |
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| Title |
SNORD80-guided 2’-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses. |
| 490 0# - SERIES STATEMENT |
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| Series statement |
Proceedings of the National Academy of Sciences, 122(7), e2418996122, 2025. |
| 500 ## - GENERAL NOTE |
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| General note |
Artículo |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
The introns of the gene encoding the long noncoding RNA (lncRNA) GAS5 host up to 10 C/D box small nucleolar RNAs (snoRNAs). However, whether there is a regulatory and functional relationship between these snoRNAs and GAS5 is unknown. Here, we show that the expression of SNORD80, but not the other snoRNAs, parallels GAS5 expression and is regulated alongside GAS5 in response to cellular stress. The 2′-O-methylation at the A496 site, located within a segment of GAS5 complementing the conserved RNA-binding region on SNORD80, promotes GAS5 stability and consequent upregulation. This methylation requires SNORD80, as it is diminished by knockdown of SNORD80 and increased by SNORD80 overexpression, similar to the effects of manipulating the expression of fibrillarin, the methyltransferase of the box C/D small nucleolar ribonucleoprotein particle (snoRNP). The upregulation of SNORD80 in response to cellular stress is due to an enhancement in its stability, which is associated with an increase in its interaction with fibrillarin. Collectively, these results identify a role for SNORD80 in guiding 2′-O-methylation to stabilize GAS5. This uncovers a feedforward regulatory loop at the GAS5 gene locus in response to cellular stress and sheds light on posttranscriptional mechanisms governing lncRNA expression. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CHROMOSOMAL PROTEINS, NON-HISTONE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
HUMANS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
METHYLATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
RNA STABILITY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
RNA, LONG NONCODING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
RNA, SMALL NUCLEOLAR |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
STRESS, PHYSIOLOGICAL |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Xu, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zhao, X. H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zhang, Y. Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zhang, M. Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zhang, L. Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Ye, K. H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Jin, L. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/13UTWtSiNMkhFWjPds4lpO0uXooHSEz7B/view?usp=drive_link">https://drive.google.com/file/d/13UTWtSiNMkhFWjPds4lpO0uXooHSEz7B/view?usp=drive_link</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
