MARC details
| 000 -LEADER |
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| fixed length control field |
02213nam a2200313Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251009160711.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-21966 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
251009s9999 xx 000 0 und d |
| 245 10 - TITLE STATEMENT |
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| Title |
13C NMR-based dereplication analysis of cytotoxic styryl lactones from Goniothalamus giganteus against OSCC. |
| 490 0# - SERIES STATEMENT |
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| Series statement |
Journal of Molecular Structure, 1308, 138245, 2024. |
| 500 ## - GENERAL NOTE |
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| General note |
Artículo |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Styryl lactones, which are ubiquitous in the genus Goniothalamus, have emerged as promising candidates in combating cancer due to their ability to inhibit the growth of cancer cells. Therefore, this study aimed to rapidly identify styryl lactones from the bark of a Malaysian plant, Goniothalamus giganteus, by combining conventional phytochemical methods with 13C NMR-based dereplication analysis to speed up the chemical profiling and structural elucidation processes. From the 13C NMR-based dereplication analysis of Goniothalamus giganteus using MixONat software, a total of nineteen compounds were identified; two terpenes (1-2), one flavonoid (3), and sixteen styryl lactones (4-19). Purification exercise led to the isolation of thirteen compounds, including two new compounds possessing a bis-styryllactone skeleton; goniogigantone A (20) and goniogigantone B (21), along with other eleven known compounds (1, 3, 9, 11, 12, 14, 17, 22-25). Altholactone (11), the major compound isolated from this species had showed the highest cytotoxic effect against both H103 and H400 oral squamous cell carcinoma (OSCC) cell lines with IC50 values of 5.68 μM and 5.08 μM, respectively via MTT assay. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
GONIOTHALAMUS GIGANTEUS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
13C NMR-BASED DEREPLICATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MIXONAT |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CYTOTOXIC |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
OSCC |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Abd Rahman, S. N. A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Derbré, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Rahman, S. N. S. A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Yap, L. F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Lim, C. W. B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Tan, S. P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Othman, M. A. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1IxGtNxlIaSIf2SLTjshqbEg3HmSpkTsz/view?usp=drive_link">https://drive.google.com/file/d/1IxGtNxlIaSIf2SLTjshqbEg3HmSpkTsz/view?usp=drive_link</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
