Identification of FBLL1 as a neuron-specific RNA 2′-O-methyltransferase mediating neuronal differentiation. (Record no. 62080)
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| fixed length control field | 02393nam a2200313Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20251009160712.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-21992 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251009s9999 xx 000 0 und d |
| 245 10 - TITLE STATEMENT | |
| Title | Identification of FBLL1 as a neuron-specific RNA 2′-O-methyltransferase mediating neuronal differentiation. |
| 490 0# - SERIES STATEMENT | |
| Series statement | Proceedings of the National Academy of Sciences, 121(48), e2406961121, 2024. |
| 500 ## - GENERAL NOTE | |
| General note | Artículo |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | 2′-O-methylation is one of the most prevalent RNA modifications found in different RNA types. However, the identities of enzymes participating in the transfer of methyl groups are not well defined. To date, fibrillarin (FBL) is the only known small nucleolar ribonucleoprotein (snoRNP) 2′-O-methyltransferase. Whether other snoRNP 2′-O-methyltransferases exist and their functions in targeting RNAs to determine cell differentiation and function need to be elucidated. Here, we identify FBL-like protein 1 (FBLL1) as a 2′-O-methyltransferase and find its function in promoting neuronal differentiation. We show that FBLL1 is a key snoRNP complex enzyme that transfers methyl groups to substrate RNAs both in vitro and in vivo. Moreover, FBLL1 exhibits different 2′-O-methyltransferase site selectivity from FBL and tissue-specific distribution. FBLL1 is preferentially expressed in the brain, especially in human neuron cells, and promotes neuronal differentiation through 2′-O-methylation of GAP43 messenger RNA (mRNA). Knockdown of FBLL1, but not FBL, reduced 2′-O-methylation levels in GAP43 mRNA, decreased expression of GAP43 proteins, and eventually repressed neuronal differentiation. Our finding of neuron-specific FBLL1 adds insights into RNA modification in neurobiology and provides clues for understanding 2′-O-methylation in health and disease. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | RNA MODIFICATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | RNA METHYLTRANSFERASE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | 2′- O- METHYLATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | FIBRILLARIN LIKE PROTEIN 1 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | NEURONAL DIFFERENTIATION |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xu, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ma, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ge, W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cao, X. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1IbRXlOamnBKrG509rgZBrNjiMKq68Tl_/view?usp=drive_link">https://drive.google.com/file/d/1IbRXlOamnBKrG509rgZBrNjiMKq68Tl_/view?usp=drive_link</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 09.10.2025 | B-21992 | 09.10.2025 | 09.10.2025 | Documentos solicitados |