RNA interference

Tipo de material: Texto

TextoSeries ; Nature, 418, p.244-251 , 2002Trabajos contenidos:

Hannon, G.J

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Resumen: A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi)or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.

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A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi)or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.

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