Image from Google Jackets

Cytotoxic and DNA interaction activities of extracts from medicinal plants used in Argentina

Tipo de material: TextoTextoSeries ; Journal of EthnoPharmacology, 71(1-2), p.145-151, 2000Trabajos contenidos:
  • Mongelli, E
  • Pampuro, S
  • Coussio, J
  • Salomon, H
  • Ciccia, G
Tema(s): Recursos en línea: Resumen: Eight crude extracts from seven Argentine plants with cancer-related ethnobotanical uses have been subjected to a bioscreening study to detect cytotoxic activity. The plants studied were: Aristolochia triangularis, Baccharis grisebachii, Bolax gummifera, Eupatorium hecatanthum, Erythrina crista-galli, Pterocaulon polystachium and Salpichroa origanifolia. Crown gall tumour inhibition, DNA interaction and cytotoxicity towards KB cells were assayed using the potato disc, the DNA-methyl green (DNA-MG)and the KB cells cytotoxicity bioassays respectively. The results obtained indicate that A. triangularis (ED50=47 g/ml), B. gummifera (ED50=32 g/ml)and E. hecatanthum (ED50=35 g/ml)contained cytotoxic compounds against KB cells. All of the plants studied inhibited the growth of crown gall tumours, showing correlation between the experimental data and the uses reported for these plants. Moreover, the results obtained for the extracts of E. hecatanthum and P. polystachium indicate the presence of compounds that interact with DNA (48 and 22
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Collection Call number Status Date due Barcode
Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-6400 (Browse shelf(Opens below)) Available

Eight crude extracts from seven Argentine plants with cancer-related ethnobotanical uses have been subjected to a bioscreening study to detect cytotoxic activity. The plants studied were: Aristolochia triangularis, Baccharis grisebachii, Bolax gummifera, Eupatorium hecatanthum, Erythrina crista-galli, Pterocaulon polystachium and Salpichroa origanifolia. Crown gall tumour inhibition, DNA interaction and cytotoxicity towards KB cells were assayed using the potato disc, the DNA-methyl green (DNA-MG)and the KB cells cytotoxicity bioassays respectively. The results obtained indicate that A. triangularis (ED50=47 g/ml), B. gummifera (ED50=32 g/ml)and E. hecatanthum (ED50=35 g/ml)contained cytotoxic compounds against KB cells. All of the plants studied inhibited the growth of crown gall tumours, showing correlation between the experimental data and the uses reported for these plants. Moreover, the results obtained for the extracts of E. hecatanthum and P. polystachium indicate the presence of compounds that interact with DNA (48 and 22

There are no comments on this title.

to post a comment.