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In vivo antitumor activity by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalconein a solid human carcinoma xenograft model

Tipo de material: TextoTextoSeries ; Cancer Chemother Pharmacol, 56(1), p.70-74, 2005Trabajos contenidos:
  • Ye, Ch.L
  • Liu, J.W
  • Wei, D.Z
  • Lu, Y.H
  • Qian, F
Tema(s): Recursos en línea: Resumen: Previously we have shown that 2¢,4¢-dihydroxy- 6'-methoxy-3',5'-dimethylchalcone (DMC), which is isolated from the buds of Cleistocalyx operculatus, significantly inhibits the growth of human liver cancer SMMC-7721 cells and is able to induce apoptosis of SMMC-7721 cells in vitro. Here we report the antitumor effects of DMC in vivo, using a solid human tumor xenograft mouse model using human liver cancer SMMC-7721 cells. The average tumor weights in the control group and in mice injected with 150 mg/kg DMC were 1.42±0.11 g and 0.59±0.12 g, respectively. Flow cytometric analysis of the tumor cell population demonstrated an aneuploid peak (representing 33.60±0.80
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Previously we have shown that 2¢,4¢-dihydroxy- 6'-methoxy-3',5'-dimethylchalcone (DMC), which is isolated from the buds of Cleistocalyx operculatus, significantly inhibits the growth of human liver cancer SMMC-7721 cells and is able to induce apoptosis of SMMC-7721 cells in vitro. Here we report the antitumor effects of DMC in vivo, using a solid human tumor xenograft mouse model using human liver cancer SMMC-7721 cells. The average tumor weights in the control group and in mice injected with 150 mg/kg DMC were 1.42±0.11 g and 0.59±0.12 g, respectively. Flow cytometric analysis of the tumor cell population demonstrated an aneuploid peak (representing 33.60±0.80

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