SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis

Tipo de material: Texto

TextoSeries ; FEBS Letters, p.1973-1977, 2005Trabajos contenidos:

Thevissen, K

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Resumen: The antifungal plant defensin DmAMP1 interacts with the fungal sphingolipid mannosyl diinositolphosphoryl ceramide (M(IP)2C)and induces fungal growth inhibition. We have identified SKN1, besides the M(IP)2C-biosynthesis gene IPT1, as a novel DmAMP1-sensitivity gene in Saccharomyces cerevisiae. SKN1 was previously shown to be a KRE6 homologue, which is involved in b-1,6-glucan biosynthesis. We emonstrate that a Dskn1 mutant lacks M(IP)2C. Interestingly, overexpression of either IPT1 or SKN1 complemented the skn1 mutation, conferred sensitivity to DmAMP1, and resulted in M(IP)2C levels comparable to the wild type. These results show that SKN1, together with IPT1, is involved in sphingolipid biosynthesis in S. cerevisiae.

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Previous	B-7478 E2F and Signal Transduction Pathways	B-7479 Temporal control of cell cycle gene expression mediated by E2F transcription factors	B-748 Kinetics of a model for nucleation-controlled polymer crystal growth	B-7480 SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis	B-7481 Isolation and characterization of Neurospora crassa mutants resistant to antifungal plant defensins	B-7482 Neutral glycolipids of the filamentous fungus Neurospora crassa : altered expression in plant defensin-resistant mutants	B-7483 Relevance of microbial extracellular polymeric substances (EPSs)- Part I: Structural and ecological aspects	Next

The antifungal plant defensin DmAMP1 interacts with the fungal sphingolipid mannosyl diinositolphosphoryl ceramide (M(IP)2C)and induces fungal growth inhibition. We have identified SKN1, besides the M(IP)2C-biosynthesis gene IPT1, as a novel DmAMP1-sensitivity gene in Saccharomyces cerevisiae. SKN1 was previously shown to be a KRE6 homologue, which is involved in b-1,6-glucan biosynthesis. We emonstrate that a Dskn1 mutant lacks M(IP)2C. Interestingly, overexpression of either IPT1 or SKN1 complemented the skn1 mutation, conferred sensitivity to DmAMP1, and resulted in M(IP)2C levels comparable to the wild type. These results show that SKN1, together with IPT1, is involved in sphingolipid biosynthesis in S. cerevisiae.

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