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G1 to S transition: more than a cell cycle engine switch

Tipo de material: TextoTextoSeries ; Current Opinion in Plant Biology, 5(6), p.480-486, 2002Trabajos contenidos:
  • Gutierrez, C
  • Ramirez-Parra, E
  • Castellano, M.M
  • del Pozo, J.C
Recursos en línea: Resumen: CDK-cyclin complexes are the universal drivers of cell cycle transitions. Progression through G1 and transition to S-phase, thereby initiating genome duplication, requires the concerted action of cyclin-dependent kinase (CDK)-cyclin complexes on specific targets. These targets belong to at least two major regulatory networks: the retinoblastoma-related (RBR)/E2F pathway and complexes that are responsible for the initiation of DNA replication. The G1 phase is central to the integration of signals that regulate both the exit from the cell division cycle to differentiation and the reactivation of cell proliferation. Cellular factors that are involved in these pathways play a role in regulating cell size and number, and organogenesis. As a consequence, they are also involved in determining plant architecture.
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CDK-cyclin complexes are the universal drivers of cell cycle transitions. Progression through G1 and transition to S-phase, thereby initiating genome duplication, requires the concerted action of cyclin-dependent kinase (CDK)-cyclin complexes on specific targets. These targets belong to at least two major regulatory networks: the retinoblastoma-related (RBR)/E2F pathway and complexes that are responsible for the initiation of DNA replication. The G1 phase is central to the integration of signals that regulate both the exit from the cell division cycle to differentiation and the reactivation of cell proliferation. Cellular factors that are involved in these pathways play a role in regulating cell size and number, and organogenesis. As a consequence, they are also involved in determining plant architecture.

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