A simple procedure for the solid phase synthesis of unsymmetrically functionalised diamides from symmetric diacids
Tipo de material:
TextoSeries ; Tetrahedron Letters, 40(2), p.235-238, 1996Trabajos contenidos: - Wahhab, A
- Leban, J
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The solid phase synthesis of unsymmetrically substituted diamides from symmetric dicarboxylic acids is described. The process was conducted following these steps: (1)preactivation of the dicarboxylic acid with BOP, (2)addition to amine resin, (3)reaction with a second amine, and (4)TFA cleavage to afford the desired diamide. Most of the unsymmetric diamides were obtained in >80
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