Antiviral Activity of Sanicula europaea L. Extracts on Multiplication of Human Parainfluenza Virus Type 2

Tipo de material: Texto

TextoSeries ; Phytotherapy Research, 13(5), p.436-438, 1999Trabajos contenidos:

Karago, A
Arda, N
Goren, N
Nagata, K
Kuru, A

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Resumen: The antiviral activity of Sanicula europaea L. extracts against human parainfluenza virus type 2 (HPIV- 2)was examined. The extract prepared from the leaves of the plant and a fraction separated from the crude extract with gel filtration chromatography were found to inhibit HPIV-2 replication without any toxic effect on Vero cells. The acidic fraction obtained from the crude extract of S. europaea leaves was found to be the most active fraction with plaque inhibition assay at non-cytotoxic concentrations. Unfortunately, antiviral activity was not detected in the molecules purified from the crude ethanol extract of Sanicula leaves.

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Item type	Current library	Collection	Call number	Status	Date due	Barcode
Documentos solicitados	CICY Documento préstamo interbibliotecario	Ref1	B-7890 (Browse shelf(Opens below))	Available

The antiviral activity of Sanicula europaea L. extracts against human parainfluenza virus type 2 (HPIV- 2)was examined. The extract prepared from the leaves of the plant and a fraction separated from the crude extract with gel filtration chromatography were found to inhibit HPIV-2 replication without any toxic effect on Vero cells. The acidic fraction obtained from the crude extract of S. europaea leaves was found to be the most active fraction with plaque inhibition assay at non-cytotoxic concentrations. Unfortunately, antiviral activity was not detected in the molecules purified from the crude ethanol extract of Sanicula leaves.

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