Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors

Tipo de material: Texto

TextoSeries ; Bioorganic & Medicinal Chemistry Letters, 14(20), p.5215-5218, 2004Trabajos contenidos:

Yahiaoui, S
Pouget, C
Fagnere, C
Champavier, Y
Habriouxa, G
Chulia, A.J

Recursos en línea:

Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx

Resumen: Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. Azole derivatives such as letrozole or anastrozole have been developed for aromatase inhibition and are used for the treatment of breast tumors. In this paper, four 4-triazolylflavans were synthesized and were found to exhibit moderate to high inhibitory activity against aromatase.

Tags from this library: No tags from this library for this title. Log in to add tags.

Average rating: 0.0 (0 votes)

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Documentos solicitados	CICY Documento préstamo interbibliotecario	Ref1	B-7898 (Browse shelf(Opens below))	Available

Browsing CICY shelves, Shelving location: Documento préstamo interbibliotecario, Collection: Ref1 Close shelf browser (Hides shelf browser)

Previous	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	Next
Previous	B-7895 Petunia Phospholipase C1 Is Involved in Pollen Tube Growth	B-7896 The Ga Protein Controls a pH-Dependent Signal Path to the Induction of Phytoalexin Biosynthesis in Eschscholzia californica	B-7897 Production of coumarins by Phytophthora infestans	B-7898 Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors	B-7899 New Aromatase Inhibitors. Synthesis and Inhibitory Activity of Pyridinyl-Substituted Flavanone Derivatives	B-79 Herbario Nacional de México : su contenido y su uso	B-790 Sheet-like material	Next

Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. Azole derivatives such as letrozole or anastrozole have been developed for aromatase inhibition and are used for the treatment of breast tumors. In this paper, four 4-triazolylflavans were synthesized and were found to exhibit moderate to high inhibitory activity against aromatase.

There are no comments on this title.

to post a comment.