Design, Synthesis and Evaluation of 4-Imidazolylflavans as New Leads for Aromatase Inhibition

Tipo de material: Texto

TextoSeries ; Bioorganic & Medicinal Chemistry Letters, 12(20), p.2859-2861, 2002Trabajos contenidos:

Pouget, Ch
Fagnere, C
Basly, J.P
Habrioux, G
Chulia, A.J

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Resumen: Abstract-Two 4-imidazolylflavans were synthesized and their relative stereochemistry was established by 1H and 13C NMR data. These compounds were tested for their activity to inhibit aromatase. It was observed that the introduction of an imidazolyl group at carbon 4 on flavan nucleus led to potent molecules.

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Abstract-Two 4-imidazolylflavans were synthesized and their relative stereochemistry was established by 1H and 13C NMR data. These compounds were tested for their activity to inhibit aromatase. It was observed that the introduction of an imidazolyl group at carbon 4 on flavan nucleus led to potent molecules.

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