Oxidative Stress Increases Susceptibility of Mycobacterium tuberculosis to Isoniazid

Tipo de material: Texto

TextoSeries ; Antimicrobial Agents and Chemotherapy, 46(9), p.2765-2771, 2002Trabajos contenidos:

Bulatovic,V.M
Wengenack, N.L
Uhl, J.R
Hall, L
Roberts, G.D
Cockerill, F.R
Rusnak, F

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Resumen: Isoniazid is a first-line antibiotic used in the treatment of infections caused by Mycobacterium tuberculosis. Isoniazid is a prodrug requiring oxidative activation by the catalase-peroxidase hemoprotein, KatG. Resistance to isoniazid can be obtained by point mutations in the katG gene, with one of the most common being a threonine-for-serine substitution at position 315 (S315T). The S315T mutation is found in more than 50

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Isoniazid is a first-line antibiotic used in the treatment of infections caused by Mycobacterium tuberculosis. Isoniazid is a prodrug requiring oxidative activation by the catalase-peroxidase hemoprotein, KatG. Resistance to isoniazid can be obtained by point mutations in the katG gene, with one of the most common being a threonine-for-serine substitution at position 315 (S315T). The S315T mutation is found in more than 50

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