Isolation of Leishmanicidal Triterpenes and Lignans from the Amazonian Liana Doliocarpus dentatus (Dilleniaceae)

Tipo de material: Texto

TextoSeries ; Phytotherapy Research, 10(1), p.1-4, 1996Trabajos contenidos:

Sauvain, Michel
Kunesch, Nicole
Poisson, Jacques
Gantier, Jean-Charles
Gayral, Philippe
Dedet, Jean-Pierre

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Resumen: The in uitro antileishmanial activity of triterpenes and lignans of an Amazonian medicinal plant, Doliocarpus dentutus (Aublet)Standley, is reported for the first time against amastigotes of Leishmania amazonensis. Terpenes, for example, betulinic acid, betulin and betulinaldehyde were isolated by bioassay-linked extraction. The lignans were characterized as (+)pinoresinol, (+)medioresinol and (-)lirioresinol B.

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The in uitro antileishmanial activity of triterpenes and lignans of an Amazonian medicinal plant, Doliocarpus dentutus (Aublet)Standley, is reported for the first time against amastigotes of Leishmania amazonensis. Terpenes, for example, betulinic acid, betulin and betulinaldehyde were isolated by bioassay-linked extraction. The lignans were characterized as (+)pinoresinol, (+)medioresinol and (-)lirioresinol B.

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