Expanding the soil antibiotic resistome: exploring environmental diversity

Tipo de material: Texto

TextoSeries ; Current Opinion in MicroBiology, 10(5), p.481-489, 2007Trabajos contenidos:

D'Costa, V.M
Griffiths, E
Wright, G.D

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Resumen: Antibiotic resistance has largely been studied in the context of failure of the drugs in clinical settings. There is now growing evidence that bacteria that live in the environment (e.g. the soil)are multi-drug-resistant. Recent functional screens and the growing accumulation of metagenomic databases are revealing an unexpected density of resistance genes in the environment: the antibiotic resistome. This challenges our current understanding of antibiotic resistance and provides both barriers and opportunities for antimicrobial drug discovery.

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Documentos solicitados	CICY Documento préstamo interbibliotecario	Ref1	B-9167 (Browse shelf(Opens below))	Available

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Antibiotic resistance has largely been studied in the context of failure of the drugs in clinical settings. There is now growing evidence that bacteria that live in the environment (e.g. the soil)are multi-drug-resistant. Recent functional screens and the growing accumulation of metagenomic databases are revealing an unexpected density of resistance genes in the environment: the antibiotic resistome. This challenges our current understanding of antibiotic resistance and provides both barriers and opportunities for antimicrobial drug discovery.

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