Relaxant action mechanism of berberine identified as the active principie of Argemone ochro/euca Sweet in guinea-pig tracheal smooth muscle

Tipo de material: Texto

TextoSeries ; Journal of Pharmacy and Pharmacology, 62(2), p.229-236, 2008Trabajos contenidos:

Sánchez-Mendoza, M.E
Castillo-Henkeland, C
Navarrete, A

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Resumen: In this study we investigated the relaxant effect of the aerial parts of Argemone ochroleuca (Papaveraceae), which is used in Mexican traditional medicine for the treatment of various respiratory diseases such as cough, bronchitis and asthma. The alkaloid berberine was identified as one of the active relaxant principies (EC50 = 118.50:1: 3.91 JLM)in the dichloromethane extract of A. ochroleuca (EC50=78.03:1:2.15 JLgml -1 with 95.12 :1:3.56

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In this study we investigated the relaxant effect of the aerial parts of Argemone ochroleuca (Papaveraceae), which is used in Mexican traditional medicine for the treatment of various respiratory diseases such as cough, bronchitis and asthma. The alkaloid berberine was identified as one of the active relaxant principies (EC50 = 118.50:1: 3.91 JLM)in the dichloromethane extract of A. ochroleuca (EC50=78.03:1:2.15 JLgml -1 with 95.12 :1:3.56

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