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Structure, dynamics and function of nuclear pore complexes

Tipo de material: TextoTextoSeries ; Trends in Cell Biology, 18(10), p.456-466, 2008Trabajos contenidos:
  • D'Angelo, M.A
  • Hetzer, M.W
Recursos en línea: Resumen: Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope, thereby connecting the nuclear interior with the cytoplasm. Until recently, these macromolecular complexes were viewed as static structures, the only function of which was to control the molecular trafficking between the two compartments. It has now become evident that this simplistic scenario is inaccurate and that nuclear pore complexes are highly dynamic multiprotein assemblies involved in diverse cellular processes ranging from the organization of the cytoskeleton to gene expression. In this review, we discuss the most recent developments in the nuclearpore- complex field, focusing on the assembly, disassembly, maintenance and function of this macromolecular structure.
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Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope, thereby connecting the nuclear interior with the cytoplasm. Until recently, these macromolecular complexes were viewed as static structures, the only function of which was to control the molecular trafficking between the two compartments. It has now become evident that this simplistic scenario is inaccurate and that nuclear pore complexes are highly dynamic multiprotein assemblies involved in diverse cellular processes ranging from the organization of the cytoskeleton to gene expression. In this review, we discuss the most recent developments in the nuclearpore- complex field, focusing on the assembly, disassembly, maintenance and function of this macromolecular structure.

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