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Tyrianthinic Acids from Ipomoea tyrianthina and Their Antimycobacterial Activity, Cytotoxicity, and Effects on the Central Nervous System

Tipo de material: TextoTextoSeries ; Journal of Natural Products, 71(10), p.1686-1691, 2008Trabajos contenidos:
  • Leon-Rivera, I
  • Miron-Lopez, G
  • Molina-Salinas, G.M
Recursos en línea: Resumen: Four new partially acylated tetrasaccharides of 11-hydroxyhexadecanoic acid (1-4)were isolated from a methanolic extract of Ipomoea tyrianthina. The structures of these compounds were elucidated by spectroscopic and chemical methods. The resin glycoside composition of I. tyrianthina varied with the location of growth in Mexico. Compounds 1-4 showed antimycobacterial activity, were cytotoxic against the KB cell line, and, in a mouse model, exhibited potentiation of hypnosis induced by pentobarbital, protected against seizures induced by pentylenetetrazole, and released GABA and glutamic acid.
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Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-9958 (Browse shelf(Opens below)) Available

Four new partially acylated tetrasaccharides of 11-hydroxyhexadecanoic acid (1-4)were isolated from a methanolic extract of Ipomoea tyrianthina. The structures of these compounds were elucidated by spectroscopic and chemical methods. The resin glycoside composition of I. tyrianthina varied with the location of growth in Mexico. Compounds 1-4 showed antimycobacterial activity, were cytotoxic against the KB cell line, and, in a mouse model, exhibited potentiation of hypnosis induced by pentobarbital, protected against seizures induced by pentylenetetrazole, and released GABA and glutamic acid.

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