Synthesis and Pharmacological Activity of Betulin Dinicotinate
Tipo de material:
TextoSeries ; Russian Journal of Bioorganic Chemistry, 28, p.543-550, 2002Trabajos contenidos: - Flekhter, O.B
- Larachurina, L.T
- Nigmatullina L.R
- Sapozhnikova, T.A
- Baltina, L.A
- Zarudii, F.S
- Galin, F. Z
- Galin, F. Z
- Tolstikov, G. A
- Plyasunova, O.A
- Pokrovskii, A.G
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The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3 O ,28 O - dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, antiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids.
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